Reduction of redundancy in diabetes-related gene categories utilizing conceptual similarity and gene expression information

نویسندگان

چکیده

Insulin resistance or insulin deficiency can cause diabetes, which has a high level of glucose in the blood (American Diabetes Association 2014). It's one most pressing issues modern public health. Around 366 million individuals had diabetes 2011, according to "International Federation" (IDF). This figure is expected rise 552 by end 2030. The average score semantic measure and Pearson correlation were used create similarity index this study. Gene be determined procedure. "One" indicates perfect between two genes, whereas "zero" dissimilarity. Algorithms based on measures identify genes that genetically similar. PERL was write algorithm (Practical Extraction Reporting Language). found gene-to-gene gradually deleted redundant information. An known as "greedy" employed remove all above 0.8 threshold value. experiment using several datasets led final value 0.8.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

In vitro versus In vivo: Development-, Apoptosis-, and Implantation-Related Gene Expression in Mouse Blastocyst

Background: While mammalian embryos can adapt to their environments, their sensitivity overshadows their adaptability in suboptimal in vitro conditions. Therefore, the environment in which the gametes are fertilized or to which the embryo is exposed can greatly affect the quality of the embryo and consequently its implantation potential. Objectives:</stro...

متن کامل

identification of development and pathogenicity related gene in botrytis cinerea via digital gene expression profile

conclusions expression levels of 1,426 genes were significantly up-regulated in the mutant compared to wt. furthermore, 301 genes were down-regulated with false discovery rates (fdr) of < 0.001 and absolute value of log2 ratio of ≥ 1. results a total of 4,182,944 and 4,182,021 clean tags were obtained from the wt and a nonpathogenic mutant stain (bct89), respectively, and 10,410 differentially ...

متن کامل

Integration and Reduction of Microarray Gene Expressions Using an Information Theory Approach

The DNA microarray is an important technique that allows researchers to analyze many gene expression data in parallel. Although the data can be more significant if they come out of separate experiments, one of the most challenging phases in the microarray context is the integration of separate expression level datasets that have gathered through different techniques. In this paper, we prese...

متن کامل

Utilizing Evolutionary Information and Gene Expression Data for Estimating Gene Networks with Bayesian Network Models

Since microarray gene expression data do not contain sufficient information for estimating accurate gene networks, other biological information has been considered to improve the estimated networks. Recent studies have revealed that highly conserved proteins that exhibit similar expression patterns in different organisms, have almost the same function in each organism. Such conserved proteins a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: International Journal of Health Sciences (IJHS)

سال: 2022

ISSN: ['2550-6978', '2550-696X']

DOI: https://doi.org/10.53730/ijhs.v6ns4.10612